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Chemical Structure : GKT137831
CAS No.: 1218942-37-0
Catalog No.: PC-42961Not For Human Use, Lab Use Only.
GKT137831 (Setanaxib, GKT-137831) is a potent, selective, dual NADPH oxidase Nox1/4 inhibitor with Ki of 110/140 nM, 15-fold less potent on Nox2 and 3-fold less potent on Nox5, and no affinity for xanthine oxidase.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $328 | In stock | |
| 100 mg | $528 | In stock | |
| 250 mg | Get quote |
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GKT137831 (Setanaxib, GKT-137831) is a potent, selective, dual NADPH oxidase Nox1/4 inhibitor with Ki of 110/140 nM, 15-fold less potent on Nox2 and 3-fold less potent on Nox5, and no affinity for xanthine oxidase.
GKT137831 (Setanaxib) attenuates liver fibrosis and ROS production in both SOD1mu and WT mice, suppresses ROS production and NOX and fibrotic gene expression, but not Rac1 activity, in SOD1mut and WT in hepatic stellate cells (HSCs).
| M.Wt | 394.8542 | |
| Formula | C21H19ClN4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 37 mg/mL |
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| Chemical Name/SMILES |
1H-Pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione, 2-(2-chlorophenyl)-4-[3-(dimethylamino)phenyl]-5-methyl- |
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1. Jiang JX, et al. Free Radic Biol Med. 2012 Jul 15;53(2):289-96.
2. Aoyama T, et al. Hepatology. 2012 Dec;56(6):2316-27.
3. Gray SP, et al. Circulation. 2013 May 7;127(18):1888-902.
4. Laleu B, et al. J Med Chem. 2010 Nov 11;53(21):7715-30.
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