Chemical Structure : GLUT8 inhibitor P20
CAS No.:
GLUT8 inhibitor P20
Catalog No.: PC-25531Not For Human Use, Lab Use Only.
GLUT8 inhibitor P20 is a selective inhibitor of glucose transporter GLUT8 (SLC2A8) with IC50 of 2.1 uM, 2.9-fold selective over GLUT2.
Bulk size, bulk discount!
Welcome credit card payment!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
GLUT8 inhibitor P20 is a selective inhibitor of glucose transporter GLUT8 (SLC2A8) with IC50 of 2.1 uM, 2.9-fold selective over GLUT2.
GLUT8 inhibitor P20 is selective for GLUT8 against other class I GLUTs: GLUT1, -3, and -4, as well as the GLUT5 fructose-only transporter
GLUT8 inhibitor P20 also inhibits GLUT8-mediated fructose uptake with IC50 of 2.1 uM.
GLUT8 inhibitor P20 (10 uM) reverses fructose-induced suppression of key fasting-responsive genes in hepatocytes, induces fasting signaling factors fibroblast growth factor 21 (FGF2134,35) and PGC1α.
GLUT8 inhibitor P20 reversed fructose-induced hepatocyte TG accumulation, lowered fructose-induced inflammatory gene markers Il6, Cxcl2, and Tgf-β and glutamine metabolic genes Glul and Slc25a13.
Physicochemical Properties
|
M.Wt
|
333.35
|
|
Formula
|
C19H15N3O3
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
3-(furan-2-yl)-N-(2-(pyridin-4-yl)benzo[d]oxazol-5-yl)propanamide
|
References
1. Adams JA, et al. Hepatol Commun. 2025 Sep 22;9(10):e0810.
Contact Us
sales@probechem.com
