Catalog No.: PC-60269Not For Human Use, Lab Use Only.
GPER antagonist G36 is a potent, selective, cell-permeable GPER/GPR30 antagonist that inhibits activation by either 17β-estradiol or the GPER-selective agonist G-1 with IC50 of 112 nM and 165 nM, respectively.
GPER antagonist G36 is a potent, selective, cell-permeable GPER/GPR30 antagonist that inhibits activation by either 17β-estradiol or the GPER-selective agonist G-1 with IC50 of 112 nM and 165 nM, respectively.
GPER antagonist G36 has no detectable binding activity to either ERα or ERβ.
GPER antagonist G36 inhibits estrogen- and G-1-mediated calcium mobilization as well as ERK1/2 activation, with no effect on EGF-mediated ERK1/2 activation.
