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Chemical Structure : GZ-793A
Catalog No.: PC-47108Not For Human Use, Lab Use Only.
GZ-793A is a potent, selective inhibitor of vesicular monoamine transporter-2 (VMAT2) with Ki of 30 nM, inhibits methamphetamine-evoked endogenous dopamine release with IC50 of 10.6 uM.
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GZ-793A is a potent, selective inhibitor of vesicular monoamine transporter-2 (VMAT2) with Ki of 30 nM, inhibits methamphetamine-evoked endogenous dopamine release with IC50 of 10.6 uM.
GZ-793A (15 mg/kg, s.c.) specifically decreased methamphetamine (METH) self-administration, without the development of tolerance.
GZ-793A did not serve as a substitute for self-administered METH.
GZ-793A blocked METH-induced conditioned place preference (CPP) and did not induce CPP alone.
| M.Wt | 464.043 | |
| Formula | C26H38ClNO4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Beckmann JS, et al. Psychopharmacology (Berl). 2012 Mar;220(2):395-403.
2. Horton DB, et al. J Pharmacol Exp Ther. 2011 Oct;339(1):286-97.
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