Catalog No.: PC-60057Not For Human Use, Lab Use Only.
Gedatolisib (PF-05212384, PKI-587) is a highly potent, selective, dual PI3K/mTOR inhibitor with IC50 of 0.4/6/8/6/1.6 nM for PI3Kα/β/γ/δ/mTOR, respectively.
Gedatolisib (PF-05212384, PKI-587) is a highly potent, selective, dual PI3K/mTOR inhibitor with IC50 of 0.4/6/8/6/1.6 nM for PI3Kα/β/γ/δ/mTOR, respectively.
PF-05212384 also potently inhibits PI3Kα mutant H1047R and E545K with IC50 of 0.6 and 0.6 nM.
PF-05212384 prevents the pAkt at Thr 308 with IC50 of 8 nM, and suppresses pAkt S473 with IC50 of <10 nM in cells.
PF-05212384 demonstrates antitumor efficacy in both subcutaneous and orthotopic xenograft tumor models.
