Grazoprevir | HCV NS3/4A inhibitor | Probechem Biochemicals

Chemical Structure : Grazoprevir

CAS No.: 1350514-68-9

Grazoprevir (MK-5172, MK5172)

Catalog No.: PC-25228Not For Human Use, Lab Use Only.

Grazoprevir (MK-5172) is a potent, selective inhibitor of HCV NS3/4A protease with broad activity across genotypes and resistant variants, with Ki values of 0.01 nM (gt1b), 0.01 nM (gt1a), 0.08 nM (gt2a), 0.15 nM (gt2b), 0.90 nM (gt3a), respectively, also inhibits SARS-CoV-2 3CLpro activity.

Packing	Price	Stock
2 mg	$78	In stock
5 mg	$128	In stock
10 mg	$198	In stock
25 mg	$328	In stock
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Biological Activity

Physicochemical Properties

M.Wt	766.91
Formula	C38H50N6O9S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(33R,35S,91R,92R,5S)-5-(tert-Butyl)-N-((1R,2S)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylcyclopropyl)-17-methoxy-4,7-dioxo-2,8-dioxa-6-aza-1(2,3)-quinoxalina-3(3,1)-pyrrolidina-9(1,2)-cyclopropanacyclotetradecaphane-35-carboxamide

References

1. Summa V, et al. Antimicrob Agents Chemother. 2012 Aug;56(8):4161-7.

2. Harper S, et al. ACS Med Chem Lett. 2012 Mar 2;3(4):332-6.

3. Qi Sun, et al. Signal Transduct Target Ther. 2021 May 29;6(1):212.

Grazoprevir (MK-5172, MK5172)

Biological Activity

Physicochemical Properties

References

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