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HBX 28258

Chemical Structure : HBX 28258

CAS No.: 1426544-54-8

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HBX 28258 (HBX28258)

Catalog No.: PC-62449Not For Human Use, Lab Use Only.

HBX 28258 is a potent, selective USP7 inhibitor with IC50 of 22.6 uM, exhibits high selectivity over other USP members, such as USP8, USP5, USP2, and USP20 (IC50 >200 uM), and no activity against UCH-L1, UCH-L3 and SENP1.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    HBX 28258 is a potent, selective USP7 inhibitor with IC50 of 22.6 uM.
    HBX 28258 exhibits high selectivity over other USP members, such as USP8, USP5, USP2, and USP20 (IC50 >200 uM), and no activity against UCH-L1, UCH-L3 and SENP1.
    HBX 28258 reduces HCT116 cell proliferation, induces caspase activity and PARP cleavage, and arrestes HCT116 cancer cells in G1 phase.

    Physicochemical Properties

    M.Wt 435.996
    Formula C26H30ClN3O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-Acridinecarboxamide, 9-chloro-N-[3-[ethyl(phenylmethyl)amino]propyl]-5,6,7,8-tetrahydro-

    References

    1. Reverdy C, et al. Chem Biol. 2012 Apr 20;19(4):467-77.

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