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Chemical Structure : HBX 28258
Catalog No.: PC-62449Not For Human Use, Lab Use Only.
HBX 28258 is a potent, selective USP7 inhibitor with IC50 of 22.6 uM, exhibits high selectivity over other USP members, such as USP8, USP5, USP2, and USP20 (IC50 >200 uM), and no activity against UCH-L1, UCH-L3 and SENP1.
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HBX 28258 is a potent, selective USP7 inhibitor with IC50 of 22.6 uM.
HBX 28258 exhibits high selectivity over other USP members, such as USP8, USP5, USP2, and USP20 (IC50 >200 uM), and no activity against UCH-L1, UCH-L3 and SENP1.
HBX 28258 reduces HCT116 cell proliferation, induces caspase activity and PARP cleavage, and arrestes HCT116 cancer cells in G1 phase.
| M.Wt | 435.996 | |
| Formula | C26H30ClN3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Reverdy C, et al. Chem Biol. 2012 Apr 20;19(4):467-77.
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