Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : HDAC3 inhibitor PT3
Catalog No.: PC-72343Not For Human Use, Lab Use Only.
HDAC3 inhibitor PT3 is a novel potent, selective, BBB-permeable HDAC3 inhibitor.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
HDAC3 inhibitor PT3 is a novel potent, selective, BBB-permeable HDAC3 inhibitor.
PT3 exhibited higher selectivity for HDAC3 over HDAC1, HDAC6, and HDAC8 compared to the reference compound CI994.
PT3 upregulated H3K9 acetylation, CREB 1, BDNF, TRKB, Nr4a2, c-fos, PKA, GAP 43 and MMP9 expression in mouse neuronal (N2A) cells.
PT3 significantly improved the discrimination index in C57/BL6 mice in the novel object recognition (NOR) model, significant increased in H3K9 acetylation in hippocampus.
PT3 upregulated CREB 1, BDNF, TRKB, Nr4a2, c-fos, PKA, GAP 43, PSD 95 and MMP9 expression in mice treated with PT3.
| M.Wt | 319.368 | |
| Formula | C18H17N5O | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Sravani Pulya, et al. ACS Chem Neurosci. 2021 Mar 3;12(5):883-892.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
