Chemical Structure : HDAC7 PROTAC B14
CAS No.:
2945165-63-7
HDAC7 PROTAC B14
Catalog No.: PC-24640Not For Human Use, Lab Use Only.
HDAC7 PROTAC B14 is a potent, exceedingly selective HDAC7 PROTAC degrader with DC50 of 25.1 nM in NB4 cells.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
HDAC7 PROTAC B14 is a potent, exceedingly selective HDAC7 PROTAC degrader with DC50 of 25.1 nM in NB4 cells.
B14 induced the HDAC7 degradation in a concentration-dependent manner in both DHL6 and NB4 cells.
B14 (1 μmol/L) induced a significant reduction in HDAC7 protein level was observed, reaching over 85% degradation at 24 h.
B14 exhibited specific degradation selectivity for HDAC7 over other Class I HDACs (HDAC1, HDAC2, HDAC3, HDAC8), while Class IIb HDACs (HDAC6, HDAC10).
B14 also had limited influence on the degradation of neo-substrates such as SALL4, IKZF1/3 (IKZF3 was not detected in NB4 cells in both proteomics and immunoblotting analyses), and GSPT1 in DHL6 and NB4 cells.
B14 induced a concentration-dependent cell cycle arrest in the G0 phase in DHL6 and NB4 cells, markedly inhibited cell proliferation with IC50 of 1.00 and 0.84 uM respectively.
Physicochemical Properties
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M.Wt
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992.09
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Formula
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C51H52F3N9O7S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-((1-(2-(1-(1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidine-4-carbonyl)piperidin-4-yl)ethyl)-4-(4-phenylthiazol-2-yl)piperidin-4-yl)methyl)-3-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzamide
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References
1. Yuheng Jin, et al. Acta Pharm Sin B. 2025 Mar;15(3):1659-1679.
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