Chemical Structure : HDM-201
CAS No.:
1448867-41-1
HDM-201
(NVP-HDM 201;NVP HDM201;Siremadlin)
Catalog No. : PC-70003Not For Human Use, Lab Use Only.
HDM-201 (NVP-HDM 201, Siremadlin) is a highly potent p53-MDM2 interaction inhibitor with biochemical IC50 of 0.13 nM, cellular IC50 of 90 nM.
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-7000301
Biological Activity
HDM-201 (NVP-HDM 201, Siremadlin) is a highly potent p53-MDM2 interaction inhibitor with biochemical IC50 of 0.13 nM, cellular IC50 of 90 nM.
Physicochemical Properties
M.Wt
555.4125
Formula
C26H24Cl2N6O4
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
(S)-5-(5-chloro-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)-6-(4-chlorophenyl)-2-(2,4-dimethoxypyrimidin-5-yl)-1-isopropyl-5,6-dihydropyrrolo[3,4-d]imidazol-4(1H)-one
References
1. Furet P, et al. Bioorg Med Chem Lett.
2. Chapeau EA, et al. Proc Natl Acad Sci U S A.
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