Catalog No.: PC-35319Not For Human Use, Lab Use Only.
HET0016 (HET-0016) is a potent, selective inhibitor of CYP4A, potently inhibits the formation of 20-HETE with IC50 of 8.9 nM in human renal microsomes.
HET0016 (HET-0016) is a potent, selective inhibitor of CYP4A, potently inhibits the formation of 20-HETE with IC50 of 8.9 nM in human renal microsomes.
HET0016 inhibits 20-HETE formation in rat renal microsomes with IC50 of 35 nM, shows no significant inhibition of the formation of epoxyeicosatrienoic acids (IC50=2,800 nM).
HET0016 also inhibits the CYP2C9, CYP2D6 and CYP3A4-catalysed substrates oxidation at higher concentrations (IC50=3,300, 83,900 and 71,000 nM).
HET0016 reduces protein tyrosine and p42/p44 MAPK phosphorylation, significantly inhibits the U251 proliferation and phosphorylation of both the EGFR and p42/p44 MAPK induced by EGF.
HET0016 suppresses 9L gliosarcoma cell proliferation and tumor growth in rats.
