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Chemical Structure : HG-7-92-01
CAS No.: 1315355-93-1
Catalog No.: PC-61640Not For Human Use, Lab Use Only.
HG-7-92-01 (NG25) is a potent, selective c-Fes protein-tyrosine kinase inhibitor with IC50 of 292 nM, also is a potent dual TAK1 and MAP4K2 inhibitor, with IC50s of 149 nM and 21.7 nM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 1 mg | $78 | In stock | |
| 5 mg | $188 | In stock | |
| 10 mg | $298 | In stock | |
| 25 mg | $498 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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HG-7-92-01 (NG25) is a potent, selective c-Fes protein-tyrosine kinase inhibitor with IC50 of 292 nM, also is a potent dual TAK1 and MAP4K2 inhibitor, with IC50s of 149 nM and 21.7 nM, respectively.
HG-7-92-01 (NG25) displays intermediate selectivity profiles (selectivity score=0.18) against 353 kinases.
NG25 also potently suppresses several kinases such as LYN, CSK, FER, p38α, ABL,ARG and SRC, with IC50s of 12.9, 56.4, 82.3, 102, 75.2, and 113 nM, respectively.
HG-7-92-01 (NG25) 400 nM) completely inhibits CpG B- or CpG A-stimulated secretion of IFNα and CL097-stimulated secretion of IFNβ.
HG-7-92-01 (NG25) reduces cell viability of breast cancer cell lines in a dose dependent manner.
| M.Wt | 537.587 | |
| Formula | C29H30F3N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO (5.4 mg/mL) |
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| Chemical Name/SMILES |
3-((1H-pyrrolo[2,3-b]pyridin-4-yl)oxy)-N-(4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-4-methylbenzamide |
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1. Hellwig S, et al. Chem Biol. 2012 Apr 20;19(4):529-40.
2. Weir MC, et al. PLoS One. 2017 Jul 20;12(7):e0181178.
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