Chemical Structure : HIV-1 nuclear import inhibitor H27
CAS No.:
871920-49-9
HIV-1 nuclear import inhibitor H27
Catalog No.: PC-23799Not For Human Use, Lab Use Only.
HIV-1 nuclear import inhibitor H27 is a specific HIV-1 capsid-targeting inhibitor that specifically blocks HIV-1 nuclear import, inhibits HIV-1 infection with IC50 of 1.0-2.9 µM in HeLa-R5 and 2.9-5.6 µM in primary lymphocytes.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
HIV-1 nuclear import inhibitor H27 is a specific HIV-1 capsid-targeting inhibitor that specifically blocks HIV-1 nuclear import, inhibits HIV-1 infection with IC50 of 1.0-2.9 µM in HeLa-R5 and 2.9-5.6 µM in primary lymphocytes.
H27 inhibits HIV-1 nuclear import without disrupting reverse transcription.
H27 treatment causes viral capsids to accumulate in the cytoplasm and at the nuclear envelope.
H27 does not inhibit the late assembly or maturation steps of HIV-1.
H27 may act by preventing CA from engaging with components of the NPC machinery such as TRN-1.
H27 exhibits good metabolic stability in vivo and is efficient against different subtypes and circulating recombinant forms from treatment-naïve patients as well as strains resistant to the four main classes of antiretroviral drugs.
Physicochemical Properties
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M.Wt
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637.77
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Formula
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C32H35N3O7S2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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4-((5-(tert-butyl)-2-methylphenyl)sulfonamido)-N-(4-methoxy-3-(N-(4-methoxyphenyl)sulfamoyl)phenyl)benzamide
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References
1. Boulay A, et al. EMBO Mol Med. 2024 Nov;16(11):2918-2945.
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