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Chemical Structure : HPK1 PROTAC C3
Catalog No.: PC-22897Not For Human Use, Lab Use Only.
HPK1 PROTAC C3 is a potent, selective and orally active HPK1 PROTAC degrader with DC50 of 21.26 nM, Dmax of 80.50% in Jurkat cells.
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HPK1 PROTAC C3 is a potent, selective and orally active HPK1 PROTAC degrader with DC50 of 21.26 nM, Dmax of 80.50% in Jurkat cells.
HPK1 PROTAC C3 does not significantly impact other family proteins like GCK and HGK.
HPK1 PROTAC C3 showed degradation selectivity and potent immune activation effects.
Oral administration of C3 in combination with anti-PDL1 antibody significantly inhibited tumor growth (tumor growth inhibition = 65.58%).
| M.Wt | 750.86 | |
| Formula | C43H42N8O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Mingfei Wu, et al. J Med Chem. 2024 Jul 31. doi: 10.1021/acs.jmedchem.4c00644.
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