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Chemical Structure : HS-38
CAS No.: 1030203-81-6
Catalog No.: PC-62870Not For Human Use, Lab Use Only.
HS-38 is a potent and selective DAPK1 and DAPK3 (ZIPK) inhibitor with IC50 of 200 nM for DAPK1 and Kd of 280 nM for ZIPK.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $188 | In stock | |
| 50 mg | $278 | In stock | |
| 100 mg | Get quote |
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HS-38 is a potent and selective DAPK1 and DAPK3 (ZIPK) inhibitor with IC50 of 200 nM for DAPK1 and Kd of 280 nM for ZIPK.
HS-38 also inhibits Pim3 (IC50=200 nM), and displays no activity against Src or Abl, little activity against EGFR.
HS-38 decreases RLC20 phosphorylation in cells, and decreases contractile force generated in mouse aorta, rabbit ileum, and calyculin A stimulated arterial muscle by decreasing RLC20 and MYPT1 phosphorylation.
HS-38 also promotes relaxation in Ca(2+)-sensitized vessels.
| M.Wt | 349.793 | |
| Formula | C14H12ClN5O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-[[1-(3-Chlorophenyl)-4,5-dihydro-4-oxo-1H-pyrazolo[3,4-d]pyrimidin-6-yl]thio]propanamide |
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1. Carlson DA, et al. ACS Chem Biol. 2013 Dec 20;8(12):2715-23.
2. MacDonald JA, et al. Mol Pharmacol. 2016 Jan;89(1):105-17.
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