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Chemical Structure : HSL119
Catalog No.: PC-21782Not For Human Use, Lab Use Only.
HSL119 (HSL 119) is a potent and selective hormonally upregulated neu-associated kinase (HUNK) inhibitor, completely inhibits HUNK kinase activity at 1 uM in biochemical assays.
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HSL119 (HSL 119) is a potent and selective hormonally upregulated neu-associated kinase (HUNK) inhibitor, completely inhibits HUNK kinase activity at 1 uM in biochemical assays.
HSL119 directly inhibits the activity of HUNK in HER2+ breast cancer cells.
HSL119 (1 uM) completely blocks phosphorylation of the Rubicon S92 phosphorylation site in vitro.
HSL119 inhibits survival of human HER2+ breast cancer cells with IC5o of 1.7 uM (JIMT-1 cell), but not inhibitors of ABL1, FLT3, and RET, JIMT-1 cells are in fact resistant to neratinib.
HSL119 results in gene expression changes equivalent to HUNK shRNA.
HSL119 (30 mg/kg) demonstrates tumor growth in mice implanted with WHIM8 PDX.
HUNK is downstream in the HER2 pathway, HUNK promotes autophagy in HER2+ breast cancer.
| M.Wt | 544.58 | |
| Formula | C30H27F3N6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Dilday T, et al. Cell Chem Biol. 2024 Jan 25:S2451-9456(24)00037-0.
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