Catalog No.: PC-21782Not For Human Use, Lab Use Only.
HSL119 (HSL-119) is a potent and selective hormonally upregulated neu-associated kinase (HUNK) inhibitor, completely inhibits HUNK kinase activity at 1 uM in biochemical assays.
HSL119 (HSL-119) is a potent and selective hormonally upregulated neu-associated kinase (HUNK) inhibitor, completely inhibits HUNK kinase activity at 1 uM in biochemical assays.
HSL119 directly inhibits the activity of HUNK in HER2+ breast cancer cells.
HSL119 (1 uM) completely blocks phosphorylation of the Rubicon S92 phosphorylation site in vitro.
HSL119 inhibits survival of human HER2+ breast cancer cells with IC5o of 1.7 uM (JIMT-1 cell), but not inhibitors of ABL1, FLT3, and RET, JIMT-1 cells are in fact resistant to neratinib.
HSL119 results in gene expression changes equivalent to HUNK shRNA.
HSL119 (30 mg/kg) demonstrates tumor growth in mice implanted with WHIM8 PDX.
HUNK is downstream in the HER2 pathway, HUNK promotes autophagy in HER2+ breast cancer.
