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Chemical Structure : HTH-02-006
CAS No.:
Catalog No.: PC-73284Not For Human Use, Lab Use Only.
HTH-02-006 is a potent, selective reversible inhibitor of NUAK1/2 with binding IC50 of 8/126 nM, respectively.
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| 5 mg | $428 | In stock | |
| 10 mg | $728 | In stock | |
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HTH-02-006 is a potent, selective reversible inhibitor of NUAK1/2 with binding IC50 of 8/126 nM, respectively.
HTH-02-006 reduces MYPT1(S445) phosphorylation in HuCCT-1 cells, suggesting NUAK1/2 inhibition.
HTH-02-006 ameliorates YAP(S127A)-induced hepatomegaly, and reduces MYPT1(S445) phosphorylation.
HTH-02-006 delays the outgrowth of YAP-induced HuCCT-1 xenograft tumors in nude mice.
HTH-02-006 downregulated E2F, EMT, and MYC hallmark gene sets after NUAK2 inhibition in PC cells.
HTH-02-006 slowed tumor growth and proliferation rates in a syngeneic allograft model and in radical prostatectomy patient derived explants.
HTH-02-006 treatment led to inactivation of YAP and the downregulation of NUAK2 and MYC protein levels.
| M.Wt | 588.450 | |
| Formula | C25H29IN6O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-(3-((5-iodo-2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin4-yl)oxy)phenyl)propionamide |
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1. Weiwei Fu, et al. Mol Carcinog. 2022 Mar;61(3):334-345.
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