Chemical Structure : HZ-086
CAS No.:
HZ-086
(HZ086)
Catalog No.: PC-24291Not For Human Use, Lab Use Only.
HZ-086 is a potent and selective inhibitor of adenosine A2A receptor (A2AR) with Ki of 1.4 nM (hA2A), >250-fold selective over A1R and A3R.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
HZ-086 is a potent and selective inhibitor of adenosine A2A receptor (A2AR) with Ki of 1.4 nM (hA2A), >250-fold selective over A1R and A3R.
HZ-086 inhibits NECA (1 μM)-induced cAMP production in HEK-293T cells overexpressing A2AR with IC50 of 48 nM.
HZ-086 effectively reduced NECA-induced ERK phosphorylation in a dose-dependent manner.
HZ-086 abolishes immunosuppressive effects of adenosine in Jurkat T cells.
HZ-086 restores the T cell-mediated cytotoxicity suppressed by adenosine.
HZ-086 suppresses tumor growth and enhances the efficacy of PD-L1 inhibitor in colon cancer model.
Physicochemical Properties
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M.Wt
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440.51
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Formula
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C24H24N8O
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(S)-3-(2-amino-6-(1-(1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)ethyl)-1H-1,2,3-triazol-4-yl)pyrimidin-4-yl)-2-methylbenzonitrile
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References
1. Wang P, et al. Eur J Pharmacol. 2025 Mar 19:177535.
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