Chemical Structure : HgCht2 inhibitor 1516b
CAS No.:
HgCht2 inhibitor 1516b
(Hg-CHI-1)
Catalog No.: PC-22580Not For Human Use, Lab Use Only.
HgCht2 inhibitor 1516b is a specific, substrate competitive small molecule cyst nematodes chitinase HgCht2 ( Hg-CHI-1) inhibitor, inhibits the hydrolytic activity of HgCht2 with Kd of 3.3 uM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
HgCht2 inhibitor 1516b is a specific, substrate competitive small molecule cyst nematodes chitinase HgCht2 ( Hg-CHI-1) inhibitor, inhibits the hydrolytic activity of HgCht2 with Kd of 3.3 uM.
HgCht2 inhibitor 1516b does not inhibit the activity of two plant GH18 chitinases: MtNFH from Medicago truncatula.
HgCht2 inhibitor 1516b binds to the substrate-binding cleft in a binding mode similar to that of SmNF-V in HgCht2.
HgCht2 inhibitor 1516b successfully suppresses the antagonism of cyst nematodes towards nitrogen-fixing rhizobia and phosphorus-absorbing arbuscular mycorrhizal symbioses.
HgCht2 inhibitor 1516b has a potential application in rescuing beneficial microorganism symbioses under nematode-infested conditions.
Physicochemical Properties
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M.Wt
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424.50
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Formula
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C26H24N4O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(E)-N-(2-(1H-indol-3-yl)ethyl)-4-((3-(pyridin-3-yl)acrylamido)methyl)benzamide
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References
1. Chen W, et al. Nat Microbiol. 2024 Jun 17. doi: 10.1038/s41564-024-01727-5.
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