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Chemical Structure : I-CBP112
CAS No.: 1640282-31-0
Catalog No.: PC-45646Not For Human Use, Lab Use Only.
I-CBP112 is a specific and potent inhibitor of CBP/p300 bromodomain with Kd of 150-170 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $248 | In stock | |
| 10 mg | $398 | In stock | |
| 25 mg | $598 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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I-CBP112 is a specific and potent inhibitor of CBP/p300 bromodomain with Kd of 150-170 nM.
I-CBP112 displaces H3K56ac from the CBP binding site with an IC50 of 170 nM.
I-CBP112 demonstrates 37-fold and 132-fold selectivity over BRD4 BD1 and BRD4 BD2, respectively.
I-CBP112 increases the cytotoxic activity of JQ1 in leukemic cells.
I-CBP112 impaires the disease-initiating self-renewal leukemic cells in vitro and in vivo without causing significant cytotoxicity.
| M.Wt | 468.5851 | |
| Formula | C27H36N2O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 32 mg/mL |
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| Chemical Name/SMILES |
1-Propanone, 1-[7-(3,4-dimethoxyphenyl)-2,3-dihydro-9-[[(3S)-1-methyl-3-piperidinyl]methoxy]-1,4-benzoxazepin-4(5H)-yl]- |
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1. Picaud S, et al. Cancer Res. 2015 Dec 1;75(23):5106-19.
2. Zucconi BE, et al. Biochemistry. 2016 Jul 12;55(27):3727-34.
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