Catalog No.: PC-26757Not For Human Use, Lab Use Only.
IAM1363 (IAM-1363, IAM-H1, ENT-H1) is a potent, irreversible and selective Type II inhibitor of HER2, prevents phosphorylation and activation of wild-type HER2 and variants with activating mutations in the tyrosine kinase domain.
IAM1363 (IAM-1363, IAM-H1, ENT-H1) is a potent, irreversible and selective Type II inhibitor of HER2, prevents phosphorylation and activation of wild-type HER2 and variants with activating mutations in the tyrosine kinase domain.
IAM1363 exhibits >500-fold biochemical selectivity for HER2 over EGFR and >400-fold cellular selectivity in HER2- versus EGFR-driven cell lines.
IAM1363 effectively inhibitsHER2-dependent cell growth and survival.
IAM1363 inhibits both wildtype HER2 and oncogenic HER2 mutants, including the recalcitrant exon 20 mutations.
