Catalog No.: PC-43200Not For Human Use, Lab Use Only.
IC261 (IC-261, SU-5607) is a potent, specific, ATP-competitive CK1delta/epsilon (CK1δ/CK1ε) with IC50 of 1 uM, does not block the activity of α, β and γ isoforms.
IC261 (IC-261, SU-5607) is a potent, specific, ATP-competitive CK1delta/epsilon (CK1δ/CK1ε) with IC50 of 1 uM, does not block the activity of α, β and γ isoforms.
IC261 specifically blocks phosphorylation in vivo of the CK1delta/epsilon phosphorylation sites in p53 in murine SV3T3 cells, inhibits cytokinesis causing a transient mitotic arrest.
IC261 reduces pancreatic tumour cell growth in vitro and in vivo, decreases the expression levels of several anti-apoptotic proteins and sensitises cells to CD95-mediated apoptosis.
