ICCB-19 is a small molecule that binds to a pocket on the N-terminal TRAF2-binding domain of TRADD (TRADD-N).
TRADD-N interacts with the C-terminal domain (TRADD-C) and TRAF2 to modulate the ubiquitination of RIPK1 and beclin 1.
ICCB-19 indirectly inhibited RIPK1, inhibited (bortezomib)-induced apoptosis and RDA with IC50 of 1 uM.
ICCB-19 effectively induced autophagy and the degradation of long-lived proteins.
Inhibition of TRADD by ICCB-19 or Apt-1 (Apostatin-1, Cat. PC-38288) blocks apoptosis and restores cellular homeostasis by activating autophagy in cells with accumulated mutant tau, α-synuclein, or huntingtin.
