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Chemical Structure : INT-767
Catalog No.: PC-43034Not For Human Use, Lab Use Only.
INT-767 (INT767) is a potent, selective, dual farnesoid X receptor (FXR) and TGR5 agonist with EC50 of 30 and 630 nM, respectively.
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INT-767 (INT767) is a potent, selective, dual farnesoid X receptor (FXR) and TGR5 agonist with EC50 of 30 and 630 nM, respectively.
INT-767 fails to activate 15 other nuclear receptors involved in metabolic pathways, and does not inhibit cytochrome P450 enzymes.
INT-767 induces FXR-dependent lipid uptake by adipocytes and promotes TGR5-dependent glucagon-like peptide-1 (GLP-1) secretion by enteroendocrine cells.
INT-767 markedly decreases cholesterol and triglyceride levels in diabetic db/db mice.
| M.Wt | 494.6601 | |
| Formula | C25H43NaO6S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 205.5 mg/mL |
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1. Rizzo G, et al. Mol Pharmacol. 2010 Oct;78(4):617-30.
2. Baghdasaryan A, et al. Hepatology. 2011 Oct;54(4):1303-12.
3. McMahan RH, et al. J Biol Chem. 2013 Apr 26;288(17):11761-70.
4. Wang XX, et al. J Biol Chem. 2017 Jul 21;292(29):12018-12024.
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