ITF-6475 | HDAC6 inhibitor | Probechem Biochemicals

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Chemical Structure : ITF-6475

ITF-6475 (ITF6475)

Catalog No.: PC-25614Not For Human Use, Lab Use Only.

ITF-6475 is a potent, selective histone deacetylase 6 (HDAC6) inhibitor with IC50 of 7.7 nM (human full-length HDAC6), ITF-6475 is highly selective for the CD2 domain (zHDAC6-CD2), shows <10,000-fold selectivity for HDAC6 over all other HDAC subtypes.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Physicochemical Properties

M.Wt	436.43
Formula	C21H18F2N8O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-(1-(4-(5-(difluoromethyl)-1,3,4-oxadiazol-2-yl)benzyl)-1H-1,2,3-triazol-4-yl)phenyl)-4,5-dihydro-1H-imidazol-2-amine

References

1. Edoardo Cellupica, et al. J Biol Chem. 2023 Jan;299(1):102800.

2. Guido Cavaletti, et al. Toxics. 2025 Sep 10;13(9):767.

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ITF-6475 (ITF6475)

Biological Activity

Physicochemical Properties

References

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