Ibrutinib (PCI-32765) | BTK inhibitor | Probechem Biochemicals

Chemical Structure : Ibrutinib

CAS No.: 936563-96-1

Ibrutinib (PCI-32765, PCI32765, PCI 32765)

Catalog No.: PC-42772Not For Human Use, Lab Use Only.

Ibrutinib (PCI-32765, PCI32765) is a potent and highly selective, covalent BTK inhibitor with IC50 of 0.5 nM.

Packing	Price	Stock
10 mg	$78	In stock
25 mg	$128	In stock
50 mg	$198	In stock
100 mg	$298	In stock
250 mg		Get quote

Get Quotation Now

* Please select Quantity before adding items.

or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Biological Activity

Ibrutinib (PCI-32765, PCI32765) is a potent and highly selective, covalent BTK inhibitor with IC50 of 0.5 nM.

Ibrutinib modestly potent to Bmx, CSK, FGR, BRK, HCK, less potent to EGFR, Yes, ErbB2, JAK3, etc.

Ibrutinib (PCI-32765) selectively inhibits B-cell signaling and activation. It inhibits autophosphorylation of Btk (IC50=11 nM), phosphorylation of Btk's physiological substrate PLCγ (IC50=29 nM).

Ibrutinib (PCI-32765) inhibits BCR-activated primary B cell proliferation (IC50=8 nM).

Following FcγR stimulation, Ibrutinib (PCI-32765) inhibits TNFα, IL-1β and IL-6 production in primary monocytes (IC50=2.6, 0.5, 3.9 nM, respectively).

Ibrutinib (PCI-32765) (3.125-50 mg/kg, p.o.) reduces the level of circulating autoantibodies and completely suppresses disease in mice with collagen-induced arthritis.

Ibrutinib (PCI-32765) (0.1 μM) inhibits activation-induced proliferation of CLL cells, induces selective cytotoxicity in B cells compared with T cells, but alters activation induced T-cell cytokine production.

Physicochemical Properties

M.Wt	440.4971
Formula	C25H24N6O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	DMSO: ≥ 52 mg/mL
Chemical Name/SMILES	2-Propen-1-one, 1-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-

References

1. Honigberg LA, et al. Proc Natl Acad Sci U S A. 2010 Jul 20;107(29):13075-80.

2. Herman SE, et al. Blood. 2014 May 22;123(21):3286-95.

3. Kohrt HE, et al. Blood. 2014 Mar 20;123(12):1957-60.

Select Your Country or Region

Ibrutinib (PCI-32765, PCI32765, PCI 32765)

Biological Activity

Physicochemical Properties

References

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

Get Quote

* Indicates a Required FieldYour information is safe with us.