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Ibrutinib

Chemical Structure : Ibrutinib

CAS No.: 936563-96-1

Ibrutinib (PCI-32765;PCI32765;PCI 32765)

Catalog No.: PC-42772Not For Human Use, Lab Use Only.

Ibrutinib (PCI-32765,PCI32765) is a potent and highly selective Btk inhibitor with IC50 of 0.5 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Ibrutinib (PCI-32765,PCI32765) is a potent and highly selective Btk inhibitor with IC50 of 0.5 nM; modestly potent to Bmx, CSK, FGR, BRK, HCK, less potent to EGFR, Yes, ErbB2, JAK3, etc.

Blood Cancer

Approved

Physicochemical Properties

M.Wt 440.4971
Formula C25H24N6O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 52 mg/mL

Chemical Name/SMILES

2-Propen-1-one, 1-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-

References

1. Honigberg LA, et al. Proc Natl Acad Sci U S A. 2010 Jul 20;107(29):13075-80.

2. Herman SE, et al. Blood. 2014 May 22;123(21):3286-95.

3. Kohrt HE, et al. Blood. 2014 Mar 20;123(12):1957-60.

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