Chemical Structure : Ifetroban sodium
CAS No.:
156715-37-6
Ifetroban sodium
(BMS-180291, CPI211)
Catalog No.: PC-20715Not For Human Use, Lab Use Only.
Ifetroban sodium (BMS-180291, CPI211) is a potent and highly selective antagonist of thromboxane A2/prostaglandin endoperoxide (TP) receptors, inhibits platelet aggregation induced by arachidonate (800 uM) and U-46,619 (10 uM) with IC50 of 7 and 21 nM, respectively.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Ifetroban sodium (BMS-180291, CPI211) is a potent and highly selective antagonist of thromboxane A2/prostaglandin endoperoxide (TP) receptors, inhibits platelet aggregation induced by arachidonate (800 uM) and U-46,619 (10 uM) with IC50 of 7 and 21 nM, respectively.
BMS 180,291 antagonized U-46,619-induced platelet shape change competitively with a KB of 11 nM.
BMS 180,291 did not inhibit platelet aggregation induced by high concentrations of ADP (20 microM) or human alpha-thrombin (1 U/ml) at 1 uM. BMS 180,291 antagonized U-46,619-induced concentrations of rat aortae with a KB of 0.6 nM.
Ifetroban sodium (BMS-180291, CPI211) potently blocked spontaneous metastasis from primary tumors, without affecting tumor cell proliferation, motility, or tumor growth.
Physicochemical Properties
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M.Wt
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462.52
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Formula
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C25H31N2NaO5
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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O=C(O[Na])CCC(C=CC=C1)=C1C[C@@H]2[C@H](C3=NC(C(NCCCCC)=O)=CO3)[C@@H]4O[C@H]2CC4
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References
1. M L Ogletree, et al. J Pharmacol Exp Ther. 1993 Feb;264(2):570-8.
2. Werfel TA, et al. 2020 Dec;19(12):2454-2464.
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