Catalog No.: PC-23926Not For Human Use, Lab Use Only.
Inotodiol (CE9A215) is a lanostane-type triterpenoid compound isolated from the sclerotia of Inonotus obliquus, a selective LXRβ agonist with EC50 of <10 nM, shows potent anti-allergic and anti-inflammatory effects.
Inotodiol (CE9A215) is a lanostane-type triterpenoid compound isolated from the sclerotia of Inonotus obliquus, a selective LXRβ agonist with EC50 of <10 nM, shows potent anti-allergic and anti-inflammatory effects. Inotodiol (CE9A215) shows no significant activation observed for LXRα at concentrations up to 1000 nM. Inotodiol (CE9A215) crosses the blood-brain barrier and accumulates in the brain. Inotodiol (CE9A215) modulated the expression of ABCA1, APOE, SREBP-1c and AQP4 in the brains of wild-type and LXR α/β knockout mice in LXRβ-dependent manner. Inotodiol (CE9A215) exerted both prophylactic and therapeutic effects on AD-associated behaviors and pathologies, including reductions in amyloid-β, phosphorylated tau, and neuroinflammation in the hippocampus in AD-related pathologies of 3xTg-AD mice.
Physicochemical Properties
M.Wt
442.73
Formula
C30H50O2
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
Lanosta-8,24-diene-3,22-diol, (3β,22R)-
References
1. Ban SY, et al. Biomed Pharmacother. 2025 Feb 6;184:117895.
2. Nakata T, et al. Bioorg Med Chem. 2007;15(1):257-264.
