J-113397 | NOP antagonist | Probechem Biochemicals

Chemical Structure : J-113397

CAS No.: 217461-40-0

J-113397 ((±)-J 113397, J113397)

Catalog No.: PC-61545Not For Human Use, Lab Use Only.

J-113397 is a potent, selective nociceptin/orphanin FQ receptor (NOP receptor/ORL1) antagonist with IC50 of 2.3 nM.

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5 mg	$238	In stock
10 mg	$378	In stock
25 mg	$598	In stock
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Biological Activity

J-113397 is a potent, selective nociceptin/orphanin FQ receptor (NOP receptor/ORL1) antagonist with IC50 of 2.3 nM.
J-113397 displays >600-fold or less affinity for mu-, delta- and kappa-opioid receptors.
J-113397 inhibits nociceptin/orphanin FQ-induced suppression of cAMP accumulation elicited by forskolin with IC50 of 26 nM.
J-113397 dose-dependently inhibits hyperalgesia elicited by nociceptin/orphanin FQ in a tail-flick test with mice.

Physicochemical Properties

M.Wt	399.57
Formula	C24H37N3O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	rel-1-[(3R,4R)-1-(Cyclooctylmethyl)-3-(hydroxymethyl)-4-piperidinyl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one

References

1. Kawamoto H, et al. J Med Chem. 1999 Dec 16;42(25):5061-3.

2. Ozaki S, et al. Eur J Pharmacol. 2000 Jan 17;387(3):R17-8.

3. Ozaki S, et al. Eur J Pharmacol. 2000 Aug 18;402(1-2):45-53.

J-113397 ((±)-J 113397, J113397)

Biological Activity

Physicochemical Properties

References

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