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Chemical Structure : J-113397
CAS No.: 217461-40-0
Catalog No.: PC-61545Not For Human Use, Lab Use Only.
J-113397 is a potent, selective nociceptin/orphanin FQ receptor (NOP receptor/ORL1) antagonist with IC50 of 2.3 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $238 | In stock | |
| 10 mg | $378 | In stock | |
| 25 mg | $598 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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J-113397 is a potent, selective nociceptin/orphanin FQ receptor (NOP receptor/ORL1) antagonist with IC50 of 2.3 nM.
J-113397 displays >600-fold or less affinity for mu-, delta- and kappa-opioid receptors.
J-113397 inhibits nociceptin/orphanin FQ-induced suppression of cAMP accumulation elicited by forskolin with IC50 of 26 nM.
J-113397 dose-dependently inhibits hyperalgesia elicited by nociceptin/orphanin FQ in a tail-flick test with mice.
| M.Wt | 399.57 | |
| Formula | C24H37N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
rel-1-[(3R,4R)-1-(Cyclooctylmethyl)-3-(hydroxymethyl)-4-piperidinyl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one |
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1. Kawamoto H, et al. J Med Chem. 1999 Dec 16;42(25):5061-3.
2. Ozaki S, et al. Eur J Pharmacol. 2000 Jan 17;387(3):R17-8.
3. Ozaki S, et al. Eur J Pharmacol. 2000 Aug 18;402(1-2):45-53.
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