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JBJ-04-125-02

Chemical Structure : JBJ-04-125-02

CAS No.: 2060610-53-7

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JBJ-04-125-02 (EGFR T790M/L858R inhibitor)

Catalog No.: PC-72984Not For Human Use, Lab Use Only.

JBJ-04-125-02 is a potent, mutant-selective, allosteric inhibitor of EGFR T790M/L858R with IC50 of 0.26 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    JBJ-04-125-02 is a potent, mutant-selective, allosteric inhibitor of EGFR T790M/L858R with IC50 of 0.26 nM.
    JBJ-04-125-02 displays excellent selectivity against a panel of 468 kinases using the KINOMEscan approach (S-Score (35)=0.02).
    JBJ-04-125-02 increases apoptosis and efficacy in vitro and in vivo compared with either single agent alone when combined with osimertinib.

    Physicochemical Properties

    M.Wt 543.617
    Formula C29H26FN5O3S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-(5-fluoro-2-hydroxyphenyl)-2-(1-oxo-6-(4-(piperazin-1-yl)phenyl)isoindolin-2-yl)-N-(thiazol-2-yl)acetamid

    References

    1. To C, et al. Cancer Discov. 2019 Jul;9(7):926-943.

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