Catalog No.: PC-73366Not For Human Use, Lab Use Only.
JBJ-09-063 is a potent, mutant-selective allosteric EGFR inhibitor against EGFR L858R, T790M and C797S mutations, with IC50 of <0.1 nM for recombinant EGFR L858R/T790M kinase domain.
JBJ-09-063 is a potent, mutant-selective allosteric EGFR inhibitor against EGFR L858R, T790M and C797S mutations, with IC50 of <0.1 nM for recombinant EGFR L858R/T790M kinase domain.
JBJ-09-063 demonstrated cell growth and EGFR phosphorylation inhibition in EGFRL858R/T790M and EGFRL858R/T790M/C797S Ba/F3 cells.
JBJ-09-063 exhibited in vivo anti-tumor activity against xenograft models harboring the EGFRL858R/T790M mutation, and EGFRL858R/T790M/C797S mutation.
