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Chemical Structure : JG-2016
Catalog No.: PC-49533Not For Human Use, Lab Use Only.
JG-2016 is a small molecule inhibitor of histone acetyltransferase 1 (HAT1) with IC50 of 14.8 uM in the HAT1 acetylation assays.
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JG-2016 is a small molecule inhibitor of histone acetyltransferase 1 (HAT1) with IC50 of 14.8 uM in the HAT1 acetylation assays.
JG-2016 binds HAT1 at the cofactor-binding site and does not compete with the histone substrate.
JG-2016 robustly inhibited cell growth (EC50=10.4 uM) in triple-negative breast cancer cell line HCC1806, inhibits A549 (lung cancer) with EC50 of 1.9 uM.
JG-2016 (50-100 mg/kg, i.p.) impairs HAT1 dependent acetylation and suppresses tumor growth with minimal toxicity in vivo.
| M.Wt | 376.841 | |
| Formula | C18H21ClN4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Gaddameedi JD, et al. J Med Chem. 2023 Apr 27;66(8):5774-5801.
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