Catalog No.: PC-25650Not For Human Use, Lab Use Only.
JH-LPH-33 is a highly potent UDP-2,3-diacylglucosamine pyrophosphate hydrolase LpxH inhibitor with IC50 of 26 nM and 46 nM for K. pneumoniae LpxH and E. coli LpxH respectively, shows antibiotic activity with MIC of 1.6 ug/mL for wild-type K. pneumoniae (ATCC 10031) in cell culture.
JH-LPH-33 is a highly potent UDP-2,3-diacylglucosamine pyrophosphate hydrolase LpxH inhibitor with IC50 of 26 nM and 46 nM for K. pneumoniae LpxH and E. coli LpxH respectively, shows antibiotic activity with MIC of 1.6 ug/mL for wild-type K. pneumoniae (ATCC 10031) in cell culture. JH-LPH-33 inhibits LpxH more potently than AZ1 (Cat#PC-25649).
1. Cho J, et al. Structural basis of the UDP-diacylglucosamine pyrophosphohydrolase LpxH inhibition by sulfonyl piperazine antibiotics. Proc Natl Acad Sci U S A. 2020 Feb 25;117(8):4109-4116.
