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You are here:Home-Chemical Inhibitors & Agonists-Membrane Transporter/Ion Channel-Monoamine Transporter-JN-170
JN-170

Chemical Structure : JN-170

CAS No.: 3032920-98-9

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JN-170 (JN170)

Catalog No.: PC-25027Not For Human Use, Lab Use Only.

JN-170 is a highly selective, first-in-class, orally bioavailable inhibitor of SLC6A19 (B0AT1) with IC50 of 97 nM against mouse SLC6A19 in the isoleucine transport assay, > 10-fold less potent against human SLC6A19 (IC50=1.25 μM).

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

JN-170 is a highly selective, first-in-class, orally bioavailable inhibitor of SLC6A19 (B0AT1) with IC50 of 97 nM against mouse SLC6A19 in the isoleucine transport assay, > 10-fold less potent against human SLC6A19 (IC50=1.25 μM).
JN-170 (50 -250 mg/kg, oral) caused a dose-dependent increase in urinary amino acid excretion in WT C57Bl/6J mice.
JN-170 significantly drove reductions in plasma Phe in an exposure-related manner.

Physicochemical Properties

M.Wt 434.42
Formula C20H21F3N6O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-N-(2-(1-aminocyclopropyl)ethyl)-3-(3-(4-cyanophenyl)-1,2,4-oxadiazol-5-yl)-3-(trifluoromethyl)pyrrolidine-1-carboxamide

References

1. Wobst HJ, et al. JCI Insight. 2024 Nov 8;9(21):e182876.

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