JNJ-10198409 |CAS:627518-40-5 Probechem Biochemicals

Chemical Structure : JNJ-10198409

JNJ-10198409 (JNJ10198409)

Catalog No.: PC-62328Not For Human Use, Lab Use Only.

JNJ-10198409 is a highly potent, selective PDGFRβ inhibitor with IC50 of 4.2 nM.

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Biological Activity

JNJ-10198409 is a highly potent, selective PDGFRβ inhibitor with IC50 of 4.2 nM; displays >10-fold selectivity over PDGFRα (IC50=45 nM), and 5-fold over c-ABL (IC50=22 nM), >500-fold over a panel of kinases; also has modest activity against have modest activity against c-Src/Lck/Fyn (IC50=185/100/378 nM); shows potent antiproliferative activity for human tumor cell lines (IC50=33 nM); regulates Oct4 and Nanog expression, cell shape, and mesenchymal stem cell potency.

Physicochemical Properties

M.Wt	325.343
Formula	C18H16FN3O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3-fluorophenyl)-1,4-dihydro-6,7-dimethoxy-indeno[1,2-c]pyrazol-3-amine

References

1. Ho CY, et al. J Med Chem. 2005 Dec 29;48(26):8163-73.

2. D'Andrea MR, et al. Mol Cancer Ther. 2005 Aug;4(8):1198-204.

3. Ball SG, et al. Stem Cells. 2012 Mar;30(3):548-60.

JNJ-10198409 (JNJ10198409)

Biological Activity

Physicochemical Properties

References

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