Catalog No.: PC-63409Not For Human Use, Lab Use Only.
JNJ-26993135 is a potent, selective leukotriene A4 hydrolase (LTA4H) inhibitor, inhibits both the epoxide hydrolase and aminopeptidase activities of recombinant human LTA4H with IC50 of 10 nM.
JNJ-26993135 is a potent, selective leukotriene A4 hydrolase (LTA4H) inhibitor, inhibits both the epoxide hydrolase and aminopeptidase activities of recombinant human LTA4H with IC50 of 10 nM.
JNJ-26993135 has no significant effects on LTC4, lipoxin A4, or PGE2 production.
JNJ-26993135 dose-dependently inhibits ex vivo LTB(4) production in blood (IC50=339 nM), in parallel with dose-dependent inhibition of neutrophil influx (ED50, 1-3 mg/kg) and ear edema in murine model of arachidonic acid-induced ear inflammation.
JNJ-26993135 selectively inhibited LTB(4) production, without affecting cysteinyl leukotriene production.
