JNJ-38877605 is a potent, selective, ATP-competitive inhibitor of catalytic activity c-Met with IC50 of 4 nM.
JNJ-38877605 exhibits >600-fold selectivity (cFMS IC50=2.6 uM, the next potently inhibited kinase) against a panel of 250 diverse tyrosine and serine-threonine kinases.
JNJ-38877605 inhibits Met phosphorylation associated with dose-dependent tumor growth inhibition in tumor xenograft models; orally bioavailable.
