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JNJ-39220675

Chemical Structure : JNJ-39220675

CAS No.: 959740-39-7

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JNJ-39220675 (JNJ39220675, JNJ 39220675)

Catalog No.: PC-61661Not For Human Use, Lab Use Only.

JNJ-39220675 is potent and selective, brain penetrant H3 antagonist with Ki of 1.4 nM, pA2 of 9.42 for hH3.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    JNJ-39220675 is potent and selective, brain penetrant H3 antagonist with Ki of 1.4 nM, pA2 of 9.42 for hH3.
    JNJ-39220675 dose-dependently reduces both alcohol intake and preference in alcohol-preferring rats.
    JNJ-39220675 reduces alcohol self-administration without changing saccharin self-administration in alcohol non-dependent rats.

    Physicochemical Properties

    M.Wt 369.44
    Formula C21H24FN3O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (4-cyclobutyl-1,4-diazepan-1-yl)(6-(4-fluorophenoxy)pyridin-3-yl)methanone

    References

    1. Letavic MA, et al. Bioorg Med Chem Lett. 2010 Jul 15;20(14):4210-4.

    2. Galici R, et al. Psychopharmacology (Berl). 2011 Apr;214(4):829-41.

    3. Nuutinen S, et al. Neuropharmacology. 2016 Jul;106:156-63.

    4. Vanhanen J, et al. Br J Pharmacol. 2013 Sep;170(1):177-87.

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