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Chemical Structure : JNJ-39220675
Catalog No.: PC-61661Not For Human Use, Lab Use Only.
JNJ-39220675 is potent and selective, brain penetrant H3 antagonist with Ki of 1.4 nM, pA2 of 9.42 for hH3.
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JNJ-39220675 is potent and selective, brain penetrant H3 antagonist with Ki of 1.4 nM, pA2 of 9.42 for hH3.
JNJ-39220675 dose-dependently reduces both alcohol intake and preference in alcohol-preferring rats.
JNJ-39220675 reduces alcohol self-administration without changing saccharin self-administration in alcohol non-dependent rats.
| M.Wt | 369.44 | |
| Formula | C21H24FN3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Letavic MA, et al. Bioorg Med Chem Lett. 2010 Jul 15;20(14):4210-4.
2. Galici R, et al. Psychopharmacology (Berl). 2011 Apr;214(4):829-41.
3. Nuutinen S, et al. Neuropharmacology. 2016 Jul;106:156-63.
4. Vanhanen J, et al. Br J Pharmacol. 2013 Sep;170(1):177-87.
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