Chemical Structure : JNJ-77242113
CAS No.:
JNJ-77242113
(JNJ-2113)
Catalog No.: PC-22797Not For Human Use, Lab Use Only.
JNJ-77242113 is a highly potent, selective, oral peptide inhibitor of IL-23 receptor with Kd of 7.1 pM, potently and selectively inhibits proximal IL-23 signaling (IC50=5.6 pM) without impacting IL-12 signaling.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
JNJ-77242113 is a highly potent, selective, oral peptide inhibitor of IL-23 receptor with Kd of 7.1 pM, potently and selectively inhibits proximal IL-23 signaling (IC50=5.6 pM) without impacting IL-12 signaling.
JNJ-77242113 inhibits IL-23–induced interferon (IFN)γ production in NK cells, and in blood from healthy donors and psoriasis patients with IC50 of 18.4, 11 and 9 pM, respectively.
JNJ-77242113 inhibits ex vivo IL-23–stimulated IL-17A production.
JNJ-77242113 inhibited IL-23–induced skin thickening and IL-17A, -17F and -22 gene induction in IL-23–induced rat skin inflammation model.
Physicochemical Properties
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M.Wt
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1898.19
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Formula
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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S3,1,S3,6-cyclo[N-acetyl-3-sulfanyl-L-valyl-L-asparaginyl-L-threonyl-7-methyl-L-tryptophyl-N6-acetyl-L-lysyl-3-sulfanyl-L-valyl-O-(2-aminoethyl)-L-tyrosyl-3-(naphthalen-2-yl)-L-alanyl-4-aminooxan-4-carbonyl-L-α-glutamyl-L-asparaginyl-3-(pyridin-3-yl)-L-alanyl-N2-methylglycinamide
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References
1. Fourie AM, et al. Sci Rep. 2024 Jul 30;14(1):17515.
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