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Chemical Structure : JNJ-77242113
Catalog No.: PC-22797Not For Human Use, Lab Use Only.
JNJ-77242113 is a highly potent, selective, oral peptide inhibitor of IL-23 receptor with Kd of 7.1 pM, potently and selectively inhibits proximal IL-23 signaling (IC50=5.6 pM) without impacting IL-12 signaling.
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JNJ-77242113 is a highly potent, selective, oral peptide inhibitor of IL-23 receptor with Kd of 7.1 pM, potently and selectively inhibits proximal IL-23 signaling (IC50=5.6 pM) without impacting IL-12 signaling.
JNJ-77242113 inhibits IL-23–induced interferon (IFN)γ production in NK cells, and in blood from healthy donors and psoriasis patients with IC50 of 18.4, 11 and 9 pM, respectively.
JNJ-77242113 inhibits ex vivo IL-23–stimulated IL-17A production.
JNJ-77242113 inhibited IL-23–induced skin thickening and IL-17A, -17F and -22 gene induction in IL-23–induced rat skin inflammation model.
| M.Wt | 1898.19 | |
| Formula | ||
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Fourie AM, et al. Sci Rep. 2024 Jul 30;14(1):17515.
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