Chemical Structure : JNJ-8003
CAS No.:
JNJ-8003
(JNJ 8003)
Catalog No.: PC-21284Not For Human Use, Lab Use Only.
JNJ-8003 is a highly potent, selective, non-nucleoside inhibitor of respiratory syncytial virus (RSV) polymerase with IC50 of 0.67 nM, shows EC50 of 0.15 nM in RSV subgenomic replicon assays.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
JNJ-8003 is a highly potent, selective, non-nucleoside inhibitor of respiratory syncytial virus (RSV) polymerase with IC50 of 0.67 nM, shows EC50 of 0.15 nM in RSV subgenomic replicon assays.
JNJ-8003 targets the RSV L + P polymerase complex in both Flashplate and gel-based 4-mer primer extension assays using the recombinant L and P viral proteins.
JNJ-8003 does not inhibit human DNA polymerases α, β, and γ, human mitochondrial RNA polymerase, and human RNA polymerase II (IC50>100 uM). JNJ-8003 inhibits viral RNA replication and transcription at the initiation and early elongation stage.
JNJ-8003 binds within the capping domain of RSV L.
Physicochemical Properties
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M.Wt
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576.52
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Formula
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C28H25F5N4O4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(S)-8-methoxy-3-methyl-N-(3,3,3-trifluoro-2-(5-fluoro-6-(4-fluorophenyl)-4-(2-hydroxypropan-2-yl)pyridin-2-yl)-2-hydroxypropyl)cinnoline-6-carboxamide
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References
1. Xiaodi Yu, et al. Commun Biol. 2023 Oct 21;6(1):1074.
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