Catalog No.: PC-21284Not For Human Use, Lab Use Only.
JNJ-8003 is a highly potent, selective, non-nucleoside inhibitor of respiratory syncytial virus (RSV) polymerase with IC50 of 0.67 nM, shows EC50 of 0.15 nM in RSV subgenomic replicon assays.
JNJ-8003 is a highly potent, selective, non-nucleoside inhibitor of respiratory syncytial virus (RSV) polymerase with IC50 of 0.67 nM, shows EC50 of 0.15 nM in RSV subgenomic replicon assays.
JNJ-8003 targets the RSV L + P polymerase complex in both Flashplate and gel-based 4-mer primer extension assays using the recombinant L and P viral proteins.
JNJ-8003 does not inhibit human DNA polymerases α, β, and γ, human mitochondrial RNA polymerase, and human RNA polymerase II (IC50>100 uM). JNJ-8003 inhibits viral RNA replication and transcription at the initiation and early elongation stage.
JNJ-8003 binds within the capping domain of RSV L.
