Chemical Structure : JPC-141
CAS No.:
1628355-29-2
JPC-141
(JPC141)
Catalog No.: PC-22085Not For Human Use, Lab Use Only.
JPC-141 is a potent, selective vesicular monoamine transporter-2 (VMAT2) inhibitor, potently inhibits [3H]dopamine uptake by VMAT2 in striatal vesicles with Ki of 52 nM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
JPC-141 is a potent, selective vesicular monoamine transporter-2 (VMAT2) inhibitor, potently inhibits [3H]dopamine uptake by VMAT2 in striatal vesicles with Ki of 52 nM.
JPC-141 displays 50 to 250-fold greater selectivity for VMAT2 over dopamine, norepinephrine and serotonin plasmalemma transporters.
JPC-141 is 57-fold more selective for inhibiting VMAT2 over [3H]dofetilide binding to hERG channels expressed by HEK293.
JPC-141 prevents the METH-induced reduction in striatal dopamine content in rats.
JPC-141 decreases METH-stimulated locomotor activity in METH-sensitized rats at doses of does not alter locomotor activity in the saline control group.
JPC-141 specifically decreased iv METH self-administration at doses that had no effect on food-maintained responding.
Physicochemical Properties
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M.Wt
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324.47
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Formula
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C21H28N2O
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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1-(2-methoxyphenethyl)-4-phenethypiperazine
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References
1. Chandler CM, et al. Biochem Pharmacol. 2024 Apr 3:116189.
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