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KAI-407

Chemical Structure : KAI-407

CAS No.: 1513879-18-9

KAI-407 (KAI407)

Catalog No.: PC-61697Not For Human Use, Lab Use Only.

KAI-407 is a potent, non-8-aminoquinoline antamalarial compound that kills Plasmodium cynomolgi early dormant liver stage parasites (IC50=0.69 uM for hypnozoites, IC50=0.64 uM for developing liver stages).

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

KAI-407 is a potent, non-8-aminoquinoline antamalarial compound that kills Plasmodium cynomolgi early dormant liver stage parasites (IC50=0.69 uM for hypnozoites, IC50=0.64 uM for developing liver stages); prevents blood stage parasitemia in mice (100mg/kg); orally bioavailable.

Physicochemical Properties

M.Wt 421.383
Formula C22H14F3N5O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-(4-cyanophenyl)-N-methyl-3-(4-(trifluoromethyl)phenyl)imidazo[1,2-a]pyrazine-6-carboxamide

References

1. Zeeman AM, et al. Antimicrob Agents Chemother. 2014;58(3):1586-95.

2. Zou B, et al. ACS Med Chem Lett. 2014 Jul 6;5(8):947-50.

3. McNamara CW, et al. Nature. 2013 Dec 12;504(7479):248-253.

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