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KHK-6

Chemical Structure : KHK-6

CAS No.:

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KHK-6 (KHK6, HPK1 inhibitor)

Catalog No.: PC-22568Not For Human Use, Lab Use Only.

KHK-6 is a potent, selective, ATP-competitive inhibitor of serine/threonine kinase hematopoietic progenitor kinase 1 (HPK1, MAP4K1) with IC50 of 20 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

KHK-6 is a potent, selective, ATP-competitive inhibitor of serine/threonine kinase hematopoietic progenitor kinase 1 (HPK1, MAP4K1) with IC50 of 20 nM.
KHK-6 (0.3 and 1 μM) blocks serine376 phosphorylation of SLP-76 by TCR signaling during T-cell activation, does not show any cytotoxic effect on Jurkat cells.
KHK-6 enhances the production of cytokines related to T-cell activation in PBMCs.
KHK-6 enhances T-cell phenotypes, enhances the tumor-killing activity of T cells.

Physicochemical Properties

M.Wt 486.97
Formula C23H23ClN4O4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-3,3-dimethylisobenzofuran-1(3H)-one

References

1. Ahn MJ, et al. PLoS One. 2024 Jun 26;19(6):e0305261.

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