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Chemical Structure : KI-301690
Catalog No.: PC-49385Not For Human Use, Lab Use Only.
KI-301690 (KI 301690) is a novel potent, specific DDR1 inhibitor, synergized with gemcitabine to suppress the growth of pancreatic cancer cells.
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KI-301690 (KI 301690) is a novel potent, specific DDR1 inhibitor, synergized with gemcitabine to suppress the growth of pancreatic cancer cells.
KI-301690 displayed the strongest binding affinity for DDR1 (percent of control [POC] = 9) through a panel of 50 oncogenic kinases at 1 uM.
KI-301690 inhibited p-DDR1 expression in a dose dependent manner in pancreatic cancer cells.
KI-301690 (1-20 uM) decreased proliferative ability in PANC-1 cells in a dose and time-dependent manner.
KI-301690 effectively inhibited expressions of major ECM components by binding collagen, increased gemcitabine sensitivity when used in combination.
KI-301690 effectively blocked DDR1/PYK2/FAK signaling in pancreatic cancer cells combined with gemcitabine.
KI-301690 (30 mg/kg) and gemcitabine (3 mg/kg) for 45 days displays antitumor effects in a pancreatic cancer xenograft model, effectively decreased the expression of p-DDR, p-PYK2, and p-FAK.
| M.Wt | 459.554 | |
| Formula | C25H29N7O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ko S, et al. Am J Cancer Res. 2022 Sep 15;12(9):4326-4342.
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