Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : KL-11743
CAS No.: 1369452-53-8
Catalog No.: PC-72556Not For Human Use, Lab Use Only.
KL-11743 (KL11743) is a potent, selective, orally bioavailable inhibitor of class I glucose transporters with IC50 of 115/137/90/68 nM for GLUT1/2/3/4, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 2 mg | $158 | In stock | |
| 5 mg | $248 | In stock | |
| 10 mg | $398 | In stock | |
| 25 mg | $588 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
KL-11743 (KL11743) is a potent, selective, orally bioavailable inhibitor of class I glucose transporters (GLUT) with IC50 of 115/137/90/68 nM for GLUT1/2/3/4, respectively.
KL-11743 demonstrated no inhibitory activity at 10 uM against hexokinase.
KL-11743 inhibited both glucose consumption, lactate secretion, and 2DG transport in HT-1080 fibrosarcoma cells, with IC50 values of 228, 234, and 87 nM, respectively, and fully inhibited glycolytic ATP production in oligomycin-treated cells with an IC50 of 127 nM.
KL-11743 had minimal off-target activity in a panel of 85 high-liability receptors and transporters and 411 human kinases.
KL-11743 dose-dependently inhibits HT-1080 cells growth (IC50=667 nM), suppresses glucose metabolism and induces redox and energetic stress.
KL-11743 inhibits the growth of TCA cycle-deficient cancers in vitro and in vivo.
| M.Wt | 522.609 | |
| Formula | C30H30N6O3 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
Acetamide, 2-[3-[6-ethoxy-4-[[4-(1H-pyrazol-4-yl)phenyl]amino]-2-quinazolinyl]phenoxy]-N-(1-methylethyl)- |
|
1. Kellen Olszewski, et al. Cell Chem Biol. 2021 Oct 22;S2451-9456(21)00441-4.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
