Catalog No.: PC-72556Not For Human Use, Lab Use Only.
KL-11743 (KL11743) is a potent, selective, orally bioavailable inhibitor of class I glucose transporters with IC50 of 115/137/90/68 nM for GLUT1/2/3/4, respectively.
KL-11743 (KL11743) is a potent, selective, orally bioavailable inhibitor of class I glucose transporters (GLUT) with IC50 of 115/137/90/68 nM for GLUT1/2/3/4, respectively.
KL-11743 demonstrated no inhibitory activity at 10 uM against hexokinase.
KL-11743 inhibited both glucose consumption, lactate secretion, and 2DG transport in HT-1080 fibrosarcoma cells, with IC50 values of 228, 234, and 87 nM, respectively, and fully inhibited glycolytic ATP production in oligomycin-treated cells with an IC50 of 127 nM.
KL-11743 had minimal off-target activity in a panel of 85 high-liability receptors and transporters and 411 human kinases.
KL-11743 dose-dependently inhibits HT-1080 cells growth (IC50=667 nM), suppresses glucose metabolism and induces redox and energetic stress.
KL-11743 inhibits the growth of TCA cycle-deficient cancers in vitro and in vivo.
