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Chemical Structure : KMN-159
Catalog No.: PC-49034Not For Human Use, Lab Use Only.
KMN-159 is a potent, selective small-molecule full agonist of the prostaglandin E2 type 4 (EP4) receptor with Ki of 0.24 nM (rEP4) and EC50 of 10.6 nM in the BMC ALP assays, with no affinity for EP2 (Ki>10,000 nM).
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KMN-159 is a potent, selective small-molecule full agonist of the prostaglandin E2 type 4 (EP4) receptor with Ki of 0.24 nM (rEP4) and EC50 of 10.6 nM in the BMC ALP assays, with no affinity for EP2 (Ki>10,000 nM).
KMN-159 demonstrates the ability to stimulate osteoblastic differentiation in vitro in total rat bone marrow from both sexes and from young and old rats as measured by induction of ALP enzyme activity, mineralized nodule formation, and osteoblast phenotype marker gene expression.
KMN-159 can increase the rate of defect closure significantly over vehicle to that equivalent to rhBMP-2 in a rat calvarial defect model.
| M.Wt | 399.479 | |
| Formula | C21H31F2NO4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Barrett SD, et al. J Med Chem. 2019 May 9;62(9):4731-4741.
2. Owen TA, et al. Gene. 2020 Jul 20;748:144668.
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