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Chemical Structure : KT-195
CAS No.: 1402612-58-1
Catalog No.: PC-61840Not For Human Use, Lab Use Only.
KT-195 is a potent and selective inhibitor of serine hydrolase ABHD6 (α/β-hydrolase domain-containing protein 6) with IC50 of 10 nM.
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|---|---|---|---|
| 5 mg | $248 | In stock | |
| 10 mg | $398 | In stock | |
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| 100 mg | Get quote |
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KT-195 (ML 295) is a potent and selective inhibitor of serine hydrolase ABHD6 (α/β-hydrolase domain-containing protein 6) with IC50 of 10 nM.
KT-195 displays negligible activity against other serine hydrolases such as DAGLβ.
KT-195 induce a significant accumulation of 2-AG in Neuro2a cells.
KT-195 inhibits A23187-stimulated arachidonic acid release (IC50=0.7 uM) and LDH release from IMLF−/−.
KT-195 inhibits MPTP formation and cell death, blocks mitochondrial calcium uptak.
| M.Wt | 438.5 | |
| Formula | C27H26N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
[4-(4'-methoxy[1,1'-biphenyl]-4-yl)-1H-1,2,3-triazol-1-yl](2-phenyl-1-piperidinyl)-methanone |
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1. Hsu KL, et al. Nat Chem Biol. 2012 Dec;8(12):999-1007.
2. Yun B, et al. J Biol Chem. 2014 Jan 17;289(3):1491-504.
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