Chemical Structure : KT-413
CAS No.:
2655656-99-6
KT-413
(KT413)
Catalog No.: PC-22767Not For Human Use, Lab Use Only.
KT-413 is a potent PROTAC degrader of IRAK4 and IMiD substrates, induces the potent degradation of IRAK4, Ikaros, and Aiolos with DC50 of 6 nM, 1 nM and 1 nM, respectively in OCI-Ly10 cells.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
KT-413 is a potent PROTAC degrader of IRAK4 and IMiD substrates, induces the potent degradation of IRAK4, Ikaros, and Aiolos with DC50 of 6 nM, 1 nM and 1 nM, respectively in OCI-Ly10 cells.
KT-413 induces the CRBN-mediated degradation of IRAK4, and to recruit and degrade the IMiD neosubstrates Ikaros and Aiolos.
KT-413 displays robust antiproliferative activity with IC50 of 11 nM against DLBCL cancer line OCI-Ly10.
KT-413 (3, 10, and 30 mg/kg, po, qd) causes complete tumor regression in MYD88 mutant ABC DLBCL model.
Physicochemical Properties
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M.Wt
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871.98
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Formula
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C45H48F3N7O6S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-(2-((1r,4r)-4-((6-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethyl)-2-azaspiro[3.3]heptan-2-yl)methyl)cyclohexyl)-5-(2-hydroxypropan-2-yl)benzo[d]thiazol-6-yl)-6-(trifluoromethyl)picolinamide
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References
1. Weiss MM, et al. J Med Chem. 2024 Jul 11;67(13):10548-10566.
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