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KT5720

Chemical Structure : KT5720

CAS No.: 108068-98-0

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KT5720

Catalog No.: PC-23453Not For Human Use, Lab Use Only.

KT5720 is a potent, cell-permeable, specific, reversible and ATP-competitive PKA inhibitor with IC50 of 3.3 uM.

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50 ug $138 In stock
100 ug $238 In stock
500 ug $598 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

KT5720 is a potent, cell-permeable, specific, reversible and ATP-competitive PKA inhibitor with IC50 of 3.3 uM.
KT5720 is effective in reversing MDR1-mediated multidrug resistance.
KT5720 also reduces the excitability of dorsal root ganglion (DRG) neurons by attenuating Hyperpolarization-activated cyclic nucleotide-gated (HCN) channel activity and reducing intracellular Ca2+ concentrations.

Physicochemical Properties

M.Wt 537.62
Formula C32H31N3O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
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Solubility

10 mM in DMSO
Chemical Name/SMILES

9,12-Epoxy-1H-diindolo[1,2,3-fg:3′,2′,1′-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, 2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-, hexyl ester, (9R,10S,12S)-

References

1. Davies SP, et al. Biochem J. 2000 Oct 1;351(Pt 1):95-105.

2. Galski H, et al. Leuk Res. 2006 Sep;30(9):1151-8.

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