Chemical Structure : KTI-218
CAS No.:
3066873-57-9
KTI-218
Catalog No.: PC-25395Not For Human Use, Lab Use Only.
KTI-218 is a small molecule inhibitor that covalently bind to cysteine-51 (Cys-51) in HPV16 E6, specifically inhibit HPV16 E6 mediate p53 degradation with EC50 of 4.2 uM in RPE-1 cells.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
KTI-218 is a small molecule inhibitor that covalently bind to cysteine-51 (Cys-51) in HPV16 E6, specifically inhibit HPV16 E6 mediate p53 degradation with EC50 of 4.2 uM in RPE-1 cells.
KTI-218 specifically reduce HPV+ cells viability with IC50 of 1-3 uM.
KTI-218 activates p53-dependent transcriptional programs associated with apoptosis and senescence, resulting in reduced tumor cell viability.
KTI-218 (50 mg/kg, s.c. injection) inhibits growth of HPV-16 expressing human cervical and oropharyngeal tumor cells in vivo.
Physicochemical Properties
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M.Wt
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490.58
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Formula
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C28H31FN4O3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(S,E)-1-(4-(6-ethoxy-2-(4-fluoro-3-methoxystyryl)quinazolin-4-yl)-2-ethylpiperazin-1-yl)prop-2-en-1-one
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References
1. Anne Rietz, et al. bioRxiv[Preprint]. 2025 Aug 28:2025.08.24.671874.
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